Methadone hydrochloride (methadone) is a potent and long-lasting synthetic painkiller (analgesic) belonging to the opioid family of drugs. It was first synthesized in the late 1930’s and has since been widely used to treat chronic pain, as well as people suffering from addiction to other opioids like heroin, hydromorphone (Dilaudid) and oxycodone中国A级毛片 (OxyContin).
Methadone figures prominently in the prescription drug addiction problem currently plaguing the U.S. A major contributor to this widespread use is its relatively low price compared to other painkillers and the liberality with which family doctors and other health care professionals prescribe it for all kinds of chronic pain.
Over 980,000 Americans are addicted to heroin. They suffer from painful withdrawal symptoms and are prescribed methadone for it. Methadone is a synthetic narcotic and provides morphine like painkilling benefits. Drug treatment centers中国A级毛片 use methadone as part of their detox programs. In recent years, methadone was implicated in the overdose deaths of many teenagers and parents began questioning the virtue of administering a narcotic to heroin addicts. Methadone proponents argued that it is less addictive than morphine or heroin, and spares patients from the severe withdrawal symptoms from these drugs.
Screening Cut-Off and Detection Time
Just like any drug, screening for methadone is guided by clear cut-off levels that vary depending upon the type of sample used. There are also different cut-off levels for screening and gas chromatography mass spectrometry (GC/MS) confirmatory testing because they use different testing methodologies.
中国A级毛片Different methods = different cut-off levels.
The immunoassay tests done during initial screening are intended to detect a wide range of compounds that are chemically similar and that react with antibodies contained in the reagents. The GC/MS confirmatory tests on the other hand look for specific metabolites that identify and quantify a specific drug.
|Screening Cut-Off||GC/MS Cut-Off (Confirmatory)||Approximate Detection Time|
|Urine Drug Test Kit||300 ng/ml|
300 ng/ml (EIA)
|150 ng/ml||Up to 3-5 days after use|
|Hair Drug Test Kit||500 pg/mg||200 pg/mg||From 7-90 days after use|
DEA Drug Class
Methadone is classified under Schedule II of the Controlled Substances Act which lists drugs, substances or chemicals that have a high potential for abuse, the usage of which can potentially lead to severe physical and psychological dependence but with accepted medical uses. Drugs under this class are considered dangerous and require a prescription.9
中国A级毛片Other examples of drugs that fall under this class include:
How Does Methadone Work?
Methadone is a depressant. Depressants are drugs that slow down the central nervous system, giving one a general feeling of relaxation, causing temporary relief from stress and anger. Methadone should not be used together with other CNS depressants (tranquilizers, sedatives, sleeping pills, phenothiazines, general anesthetics, alcohol and other opioids) as it will increase the risk of profound sedation, respiratory depression, coma or death.
Forms and Routes of Administration
Methadone is available in crystalline powder form, in pill form (sometimes called diskets/diskettes), oral solution or liquid injection.
- Oral – Some methadone tablets may be swallowed whole while others have to be dissolved in water first like the powder form. The oral solutions come either ready-to-drink or in liquid methadone concentrate form that should be mixed with water or juice first. Single doses from 80-100mg per day can last from 24-36 hours. A single dose could be 2x 40mg pills. Methadone clinics sometimes use the liquid form as they are able to control and adjust doses to as little as 1mg, just enough to curb withdrawal symptoms.
- Injection – The injection method is sometimes used by illicit methadone users. Treatment centers do not consider the injection route ideal, as it shoots the drug directly into the blood stream and patients are exposed to higher risks of diseases like AIDS.
- Diskets Dispersible
- Methadone HCl Intensol
中国A级毛片As a controlled prescription drug, methadone is indicated for the following legitimates uses:
- Reduce withdrawal symptoms in people suffering from addiction to heroin and other drugs. Methadone does this without causing the “high” characteristic of the drugs that caused the addiction.
- Relieve the pain associated with drug detox within the context drug addiction treatment, detoxification and maintenance.
中国A级毛片Ironically enough, many people end up using methadone without medical supervision for the very same reasons they are used by legitimate addiction treatment centers. Being a depressant, many people use methadone, for its sedative effects:
- To reduce physical pain (from withdrawal symptoms or other medical conditions like terminal cancer)
- To reduce/dull psychological pain
- To feel relaxed and detached
- To relieve feelings of anxiety
Street Names for Methadone
- Buzz Bomb
- Chocolate Chip Cookies
- Jungle Juice
- Red Rock
- Tootsie Roll
What is EDDP?
中国A级毛片Inside the body, methadone is primarily metabolized into an inactive metabolite called 2-Ethylidene-1,5-dimethyl-3,3-diphenyl pyrrolidine (EDDP) by the methadone-metabolizing enzymes P450 CYP 3A4, 2B6 or 2D6. Some people are genetically predisposed to be poor or non-metabolizers, but a certain percentage of the human population are what can be called rapid-metabolizers of methadone.
- Rapid Metabolizers
Rapid metabolizers, regardless of their compliance to their methadone maintenance, will not show enough parent methadone in their urine specimen to constitute a positive drug screen. They will however show a detectable amount of its metabolite, EDDP. It is important to monitor these patients by establishing expected concentrations for metabolism of methadone to EDDP. This is done by compiling urine excretion data from which proper medication (dosing) is established and toxicity is avoided.
Testing for EDDP instead of the parent drug methadone also spares these patients from being suspected of diverting their prescribed medication and being denied further doses.
- Poor and Non-Metabolizers
Poor or non-metabolizers are those who are deficient in their methadone-metabolizing enzymes P450 CYP 3A4, 2B6 or 2D6, and will therefore not form EDDP from methadone. This is seen in a sample that detected a level of methadone but not EDDP.
It is important to note however that while it is a good indication of a non-metabolizer, not all “samples-with-methadone-but-no-EDDP” indicate a non-metabolizer. Certain factors like variable doses and the length of time that has elapsed after dosing can affect the test results. It may also be an indication of sample tampering by adding methadone to the urine, resulting to a false positive.
|Test||Screening Cut-Off||Detection Time|
|Urine Drug Test Kit||300 ng/ml (EDDP)||Up to 1hr – 4days|
Methadone Side Effects
The human brain is almost entirely made up of nerve cells that communicate via neurotransmitters. Certain parts of the brain are responsible for our emotions, thought processes, speech and motor control. When , a host of problems arise.
Methadone use can cause many changes in these neurotransmitters. The nerve cells whose job it is to regulate and produce pleasure messages work overtime. The body’s reward system will send a message to repeat certain actions that produce pleasure. This is exactly what methadone does. It causes nerve cells to produce more pleasure-neurotransmitters, creating a feeling of euphoria. And since methadone is a long-acting drug, this feeling of euphoria takes a while to wear off, especially after prolonged methadone use. Eventually, neurotransmitters are over-produced, destroyed or lost, causing a chemical imbalance in the brain that will manifest into many of the following symptoms:
Short Term Effects of Methadone
|Chest Pain||Dysphoria||Irregular Heartbeat||Restlessness|
|Constipation||Facial Flushing||Light Headedness||Severe sweating|
|Death||Fainting||Mood Swings||Sexual Dysfunction|
|Depressed Reflexes||Fatigue||Muscle Flaccidity||Slow & Shallow Breathing|
|Dry Mouth||Impaired Judgment||Respiratory Depression||Vomiting|
Long Term Effects of Methadone
|Blood Damage||Depression||Muscle Flaccidity|
|Bone Damage||Emotional Instability||Pupil Constriction|
|Bone Damage||Facial Flushing||Stupor|
|Comma||Itchy Skin||Sweaty Skin|
Most cases of methadone dependence involve people who are trying to stop and are under treatment for addiction to heroin and other opioids. This is because methadone is an established drug for the management of heroin withdrawal symptoms. In the process of medical detoxification from heroin, a person can become physically and psychologically dependent on methadone. This creates a vicious cycle of addiction, and while not as incapacitating as heroin, the person nevertheless is left feeling trapped.
中国A级毛片People who use methadone for recreational purposes and without medical supervision will often show signs and experience symptoms that include the following:
- Dry mouth
- Facial flushing
- Impaired concentration
- Irregular heart beat
- Labored breathing
- Unstable gait
- Urinary retention
With close to 100 million Americans suffering from chronic pain in addition to all the heroin and opioid addicts who are trying to stop, methadone finds its way into the lives of thousands of Americans from all walks of life. Many of these people are employed and may potentially be a source of concern for employers striving to maintain a drug free workplace. For this reason, methadone is practically a standard test in multi-panel drug screens中国A级毛片 available in the market today. Any work environment can only benefit from having safety managers who are well-informed about methadone dependence and its potential effects to employees of concern, their peers and their overall productivity and safety at work.
Side Effects of Methadone Withdrawal
People who are addicted to methadone will experience painful withdrawal symptoms within the first few hours that they’re off the drug. The relaxed, laid-back feelings go away and are replaced by:
It will initially feel like the flu, with muscle aches and pains that are followed by:
- Severe nausea
These symptoms don’t go away for several days, and the person will be so miserable that they feel an even greater need to take the drug, which often leads to a cycle of further drug use and then another temporary withdrawal, only to fall back into the habit once again.
中国A级毛片Because withdrawal can cause pain, the user may feel an even greater need to take the drug. This can lead to a repeating cycle of temporary withdrawal and further drug use.
History of Methadone
中国A级毛片Methadone was first synthesized at the I.G. Farben laboratories in Germany in 1939 after a long sustained research in the area of analgetics and synthetic antipyretics that began in the early 1880’s. The compound that was later to be called methadone was originally named Va 10820.
Compound Va 10820 code-named Amidon, was given to the German Wehrmacht for further testing but was not used during the war. All known sources indicate that inadequate doses were used in the experiments, yielding unsatisfactory results.
After the war, patents, trade names and other German research assets were distributed among the allies. The U.S. confiscated I.G. Farbenkonzern’s works. By 1947, Va 10820 or Amidon was given the generic name methadone and was approved as a painkiller in the United States. The first commercial production of methadone was by under the trade name Dolophine (from the Latin dolor (pain) and finis (end)).
中国A级毛片Heroin addiction rose to epidemic proportions after the war and heroin addicts were committing crimes to get some money to feed their habit. Scientists at the Rockefeller Foundation developed a system of administering methadone to heroin addicts to prevent them from using. The system used oral administration either by liquid dose or diskettes, effectively eliminating any chance for transmission of disease. When patients were able to successfully stop committing crimes, the system was deemed successful and from there methadone treatment for heroin addiction spread across the U.S. and beyond. By 1998 New York State alone had 44,000 methadone patients, over half of the 79,000 for the entire United States.